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Written in Frustration and The Story of a Remarkable Medicine


Probability that PHT Is Effective: Page 1

  • For each of the first seven reports, controlled by phenobarbital and/or bromides, we assess the probability of being correct of 1 chance in 2.
  • Lindsley and Henry, the first paper in non-epileptics, in problem children: 1 in 2
  • Brown and Solomon, in delinquent boys: 1 in 2
  • Silverman, in a jail study, 64 prisoners, double-blind crossover, placebo-also other drugs: 5 in 6
  • Bodkin, observations of 102 nervous patients: 3 in 4
  • Goodwin, 20 patients out of 20 nervous patients: 2 in 3
  • Walker and Kirkpatrick, 10 behavioral problem children out of 10, all improved: 2 in 3
  • Zimmerman, 200 children with severe behavior disorders, 70% of cases improved: 3 in 4
  • Chao, Sexton and Davis, 296 children, response rapid, often striking: 4 in 5
  • Jonas, in his book, Ictal and Subictal Neurosis 162 patients - over 12 years: 3 in 4
  • Lynk and Amidon, 125 delinquents: 125 delinquents: 3 in 4
  • Dreyfus, 80 patients: 1 in 2
  • Rossi, behavioral problem children: 1 in 2
  • Turner, 46 of 56 adult neurotic patients: 2 in 3
  • Tec, 15 years' experience: 2 in 3
  • Boelhouwer, et al., 78 patients, double-blind crossover and placebo: 4 in 5
  • Baldwin, 109 children with behavior problems: 3 in 4
  • Stephens and Shaffer, double-blind, 30 adult outpatients: 4 in 5
  • Goldberg and Kurland, double-blind, 47 retardates, ages 9 to 14: 3 in 4
  • Daniel, aged patients: 1 in 2
  • Bozza, 21 slightly brain damaged retarded children: 1 in 2
  • Alvarez, in a book covering 25 years' experience: 5 in 6
  • Stephens and Shaffer, second double-blind with 10 patients: 3 in 4
  • Maletsky, episodic dyscontrol, 22 adults—other drugs had failed: 3 in 4
  • Maletsky and Klotter, episodic dyscontrol, 24 adults, double-blind with placebo: 4 in 5
  • Solomon and Kleeman, 2 cases episodic dyscontrol: 1 in 2
  • Bach-Y-Rita, et al., 130 adults with assaultive and destructive behavior: 3 in 4
  • Kalinowsky and Putnam, 60 psychotic patients, improvement in over half: 1 in 2
  • Freyhan, 40 psychiatric patients, behaviorial problems: 2 in 3
  • Kubanek and Rowell, double-blind, 73 psychotic patients unresponsive to other drugs: 4 in 5
  • Haward, double-blind, 20 psychotic patients: 3 in 4
  • Haward, three double-blind studies: concentration—last study, 59 pilots: 3 in 4
  • Smith and Lowrey, 20 adult volunteers, double-blind—cognitive function: 3 in 4
  • Smith and Lowrey, 10 aged adults, double-blind crossover—cognitive function: 2 in 3
  • Stambaugh, hypoglycemia, unresponsive to dietary management—including 6 hour glucose test: 3 in 4
  • Wermuth, et al., double-blind crossover, 19 "binge eaters": 2 in 3

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