• Testimonials
• Prefatory
• Brief History
• Evidence

• Benefits in Epileptics
• Benefits in Non-Epileptics
• Violent Behavior
• Psychoses (excitability, mood)
• Hypoglycemia
• Cognitive Function
• Speech Disorders
• Alcoholism and Drug Addiction
• Sleep Disorders
• Enuresis
• Anorexia, Bulimia and Binge Eating

• Cardiac Arrhythmias
• Conduction
• Q-T Interval Syndrome
• Torsade de Pointes
• Tricyclic Antidepressant Overdose
• Cardioversion
• Myocardial Infarction
• Angina Pectoris
• Hypertension
• Cerebrovascular Insufficiencies
• High-Density Lipoproteins—Atherosclerosis

• Choreas
  • Sydenham's Chorea (Chorea Minor)
  • Athetosis
• Continuous Muscle Fiber Activity
• Myotonias
  • Dystrophic and Congenita
  • Schwartz-Jampel Syndrome
• Stiff-Man Syndrome
• Parkinson’s Syndrome
• Other Muscular Disorders (Restless Legs, Steroid Myopathy, Intractable Hiccups, Respiratory Myoclonus, Palatal Myoclonus, Spasms in Multiple Sclerosis, Hypocalcemia, Tetanus)

• Trigeminal Neuralgia
• Glossopharyngeal Neuralgia
• Migraine and Other Headaches
• Post-Stroke or Brain Injury
• Other Pain and Neuralgias (Diabetic Neuropahty, Fabry's Disease, Dysesthesia (Painful Touching), Tabes, Post-Herpetic Neuralgia, Refractory Chronic Pain, Pain in Multiple Sclerosis, Abdominal Pain, Wounds, Ulcers, Burns)

• Periodontal (Caries)
• Ulcers
• Burns
• Pruritus Ani
• Scleroderma
• Localized Linear Scleroderma
• Epidermolysis Bullosa
• Pachyonychia

• Asthma
• Gastrointestinal Disorders (Irritable Bowel Syndrome, Ulcerative Colitis, Diabetic Diarrhea)
• Endocrine Disorders (Labile Diabetes, Diabetic Neuropathy, Hypoglycemia, Cushing's Syndrome, Inappropriate Antidiuretic Hormone Syndrome, Hyperthyroidism, Menstrual Disturbances)
• Fever and Temperature Regulation (Recurrent Fever, Familial Mediterranean Fever, Transfusion Reaction, Hypothalamic Syndrome)
• Granulocyte Transfusion Reaction
• Head Injuries and Surgery
• Glycogen Storage Disease
• Ophthalmology (Accomodative Esotropia, Glaucamatous Field Loss)
• Arthritis
• Rabies
• Tinnitus
• Motion Sickness

Basic Mechanisms of Action of Phenytoin

Summary

Stabilization of Bioelectrical Activity

Sodum, Potassium and Calcium Regulation

• Sodium, Potassium
• Calcium

Neurotransmitter Regulatory Effects of PHT

• Acetylcholine (ACh)
• Serotonin, Norepinephrine and Dopamine
• Gamma-aminobutyric Acid (GABA)
• Excitatory Amino Acids
• Adenosine
• Taurine
• Endorphin
• Cyclic AMP and GMP
• Calmodulin

Metabolic and Endocrine Regulatory Effects of PHT

• Carbohydrate Metabolism
• Lipid Metabolism: HDL
• Pituitary-Adrenal Hormones
• Pituitary-Thyroid Function
• Other Pituitary Hormones
• Calcitonin and Parathyroid Hormone
• Renin
• Prostaglandins

Anti-Anoxic Effects of PHT

• Cerebral
• Cardiac
• Pulmonary
• Nerve, Purkinje Fibers, Retina
• Preservation of Energy Compounds

Muscle Basic Mechanisms

• Skeletal Muscle
• Smooth Muscle

Cardiovascular Basic Mechanisms

• Cardiac Arrhythmias
• Protection Against Digitalis Toxicity
• Cardiac Conduction
• Cardiac Calcification
• Cardiac Hypoxia
• Hypertension
• High-Density Lipoproteins: Atherosclerosis

Other Studies

• Behavior and Cognitive Function
• Studies in Humans
• Sleep
• Pain
• Drug Addiction and Withdrawal
• Healing (Skin, Mucous Membranes, and Connective Tissue, Stress Ulcers, Bone, Liver, Spinal Cord, Caries)
• Temperature Regulation
• Acute Radiation Exposure
• Effects on Malignant Cell Growth
• Acquired Immunodeficiency Syndrome (AIDS)

Anti-Toxic Effects of PHT

Chemistry, Metabolism and Determination of PHT

• Chemistry and Metabolism
• Determination

Appendix

• Exchange of Letters Between Governor Nelson Rockefeller and Secretary HEW Elliott Richardson
• Survey of Use of Phenytoin in 1975
• FDA Drug Bulletin, April 1982
• Medical Journals

References

• 1-1040
• 1041-2025
• 2026-3100

Thanks