Gilles de la Tourette Syndrome

Shan, National Workshop of Clinical Use of Phenytoin, Chengdu, China (1992), 3115 reports the effect of phenytoin treatment on twelve patients with Tourette syndrome. Two patients had a reduction from tics every minute to 6 - 20 tics/day). Eight cases improved (tics/minute to tics/half hour to an hour), and only 2 cases did not improve. Among the 10 cases with Tourette syndrome who responded to phenytoin, there were 2 cases associated with enuresis and 1 case with obsessive-compulsive syndrome. During the phenytoin treatment, enuresis disappeared, and the obsessive-compulsive syndrome improved. The dosage of phenytoin is 200 mg/day for the patients less than 10 years old and 300 mg/day for those over 10 years old. For most of the patients, there was an effect after one week of treatment. When the patients stopped taking PHT, the syndrome recurred. When PHT was resumed, the syndrome improved. The author concludes that phenytoin is a useful drug for the treatment of Tourette syndrome.

3115. Shan, Y., The effect of phenytoin on Gilles de la Tourette Syndrome, Presented at the National Workshop of Clinical Use of Phenytoin, Chengdu, China, 1992.

However, the limited information available on this topic has indicated that PHT is not useful in the treatment of anger and related emotions: impatience, irritability, resentment, aggrivation, and rage.

See Also: Obsessive-compulsive disorder